PROTECT YOUR GENOME

Ionizing radiation of atomic bomb and chemicals such as anti-cancer drugs induce various types of DNA damage. The DNA damage is normally repaired by the corresponding DNA repair system; however, if an error occurs in the process of repair, the genetic information may be changed, causing various health effects such as leukemia and cancers. On the other hand, recent advances of microscope technology have revealed the very fine structures of the cell nucleus and the dynamics of various proteins in living cells. In addition, advances in image analysis technology have improved the efficiency of chromosomal image analysis drastically, making it possible to process far larger number of samples.

To study the relationship between DNA repair and higher order nuclear structure, we have applied the latest bio-imaging and biochemical technology. Besides, we aim to establish the next-generation radiology with the findings and technology obtained from these studies.


RAD51 foci
(Red: Chromosomal DNA, Green: RAD51)

NEWS & TOPICS

      
  • Oct. 1, 2024
    Mr. Namkhai Bayasgalan has joined our laboratory. He is a doctoral student in the Phoenix Leader Education Program.
  • April. 1, 2024
    Mr. Tomoki Harano, a fourth-year medical student, has been assigned as a research trainee. He is expected to deepen his understanding of medical research and develop the research mindset during the four months program.
  • Jan. 19, 2024
    The workshop “Chromosomes and Radiation,” organized by Prof. Tashiro, was held on January 19, 2024, at RIRBM, Hiroshima University.
  • Nov. 9, 2023
    Yoshitaka Kamimura, a graduate student in the MD-PhD course, was awarded the “Excellent Presentation Award” at the poster session of the 66th Annual Meeting of the Japanese Radiation Research Society held from Nov. 6 to 8, 2023.
  • April 1, 2023
    Prof. Tashiro was appointed to be the Vice-Director of Research Institute for Radiation Biology and Medicine.
  • March 31, 2023
    Prof. Tashiro has completed his second term as Director of Research Institute for Radiation Biology and Medicine.
  • Jan. 12, 2023
    The paper written by Mr. Shinya Nakayama (graduate student) et al. was published in an Oxford University Press "The Journal of Biochemistry."
    J Biochem. 2023 Jan 12. doi.org/10.1093/jb/mvad001
  • Sept. 20, 2022
    Professor Satoshi Tashiro won the Asian Association of Radiation Research (AARR) award in Senior Scientist category. He delivered a talk in the 5th Asian Congress of Radiation Research (5th ACRR-2022), which was held in Mumbai, India during Nov. 17-20, 2022.
  • June 13, 2022
    Former graduate student Dr. Atsuhiko Fukuto's article “SUMO modification system facilitates the exchange of histone variant H2A.Z-2 at DNA damage sites” (2018) is announced to be among the most highly cited in Nucleus in the last five years based on the Web of Science data.
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  • April 1, 2022
    The paper written by Mr. Shu Fujino (graduate student) et al. was published in an American journal "Radiation Research."
    Radiat Res. 2022 Jan 28. doi: 10.1667/RADE-21-00178.1.
  • April 1, 2022
    Mr. Daichi Sudo and Mr. Kohei Shimajiri, 4th graders of medical department, are assigned to our laboratory as research trainees. They are expected to understand what medical research is and to develop the research mindset through the four months of internship.
  • March 31, 2022
    Dr. Yasuha Kinugasa left Hiroshima University. As of April 1st, she is a postdoctoral researcher at Laboratory of Regulation of Intractable Infectious Diseases, National Institute of Biomedical Innovation, Health and Nutrition in Osaka.
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  • Oct. 18, 2021
    Ms. Gloriamaris L. Caraos has joined our laboratory. She is a doctoral student in the Phoenix Leader Education Program.
  • July 30, 2021
    Mr. Yoshitaka Kamimura, a 4th grader student in MD-PhD course, received “Excellent Award” at the presentation after 4 months of medical research training curriculum.
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  • July 1, 2021
    Ms. Mayumi Shigeta and Ms. Megumi Izutani have joined our laboratory as research assistants.
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  • April 1, 2021
    Ms. Aya Tanaka and Mr. Yoshitaka Kamimura, 4th graders of medical department, are assigned to our laboratory as research trainees. They are expected to understand what medical research is and to develop the research mindset through the four months of internship.
  • Dec. 30, 2020
    The paper written by Mr. Nobuki Imano (graduate student) et al. was published in an American journal "Radiation Research."
    Radiat Res. 2020 December 30;195(3):244–252. doi.org/10.1667/RADE-20-00234.1
  • Sept. 28, 2020
    Dr. Sun was awarded “Iwasaki Tamiko Prize” by the Japanese Radiation Research Society.
  • March 10, 2020
    The paper written by Mr. Hiroaki Sakane (graduate student) et al. was published in an American journal "Radiology."
    Radiology. 2020 May;295(2):439-445. doi: 10.1148/radiol.2020190389.
  • Feb. 12, 2020
    Mr. Nobuki Imano (graduate student) was awarded “Excellent Poster Award for Young Researchers” in the 4th International Symposium of the Network-type Joint Usage/Research Center for Radiation Disaster Medical Science.
  • Feb. 17-21, 2020
    HICARE/IAEA Workshop (Workshop on Biological and Internal Dosimetry; Recent advance and clinical application) was held in Kasumi Campus, Hiroshima University. Professor Tashiro organized the workshop and gave a lecture.
  • Dec. 2, 2019
    Professor Tashiro, Dr. Sun, and a couple of professors of Research Institute for Radiation Biology and Medicine of Hiroshima University visited School of Radiation Medicine and Protection, Medical College of Soochow University and shared recent achievements. These two organizations have signed an interdepartmental agreement in 2018.
  • Oct. 1, 2019
    Dr. Yasuha Kinugasa was appointed to be an assistant professor.
  • July 31, 2019
    Dr. Lin Shi has returned to China.
  • June 3, 2019
    Dr. Yasuha Kinugasa has joined our laboratory.
  • April 1, 2019
    Professor Tashiro was appointed to be the Director of Research Institute for Radiation Biology and Medicine, Hiroshima University.
    Dr. Sun was appointed to be an associate professor.
  • July 24, 2018
    The paper written by Dr. Lin Shi (assistant professor) et al. was published in an American journal "Radiation Research."
    Radiat Res. 2018 Oct;190(4):424-432. doi: 10.1667/RR14976.1.
  • May 8, 2018
    The paper written by Dr. Sun (lecturer) et al. was published in a biomedical journal “Elife.”
    Elife. 2018 May 8;7:e32222. doi: 10.7554/eLife.32222.

Chromosomal aberrations induced by irradiation (arrows)